1985年毕业于第四军医大学，先后获医学学士、硕士和博士学位。
1994年脱颖晋升副教授、1999年任教授，2000年批准为博士研究生导师。
美国Thomas Jefferson 大学和Allegheney大学心血管研究所博士后，主要从事缺血性心脏病(IHD)心肌保护的研究。
兼任国际心脏学会(IAC)学术委员会委员，中国生物物理学会理事，
欧洲心脏学会会刊Cardiovascular Research、 Apoptosis和The Open Journal of Hypertension杂志编委，
Circulation等14个SCI杂志审稿专家，《心脏杂志》常务副主编等。
首次发现胰岛素不依赖代谢调节、直接激活细胞PI3K-Akt-eNOS为主的“ 生存信号” 保护缺血心肌新机制(Circulation, 2002)，其中胰岛素直接激活心血管内源性eNOS-NO系统产生的“ 硝基酯样” 效应在GIK极化液保护缺血心脏中发挥关键作用，据此提出GIK作用机制的“ 胰岛素学说” (Cardiovasc Res, 2006,2007); 发现NO代谢产物硝酰基阴离子(NO– )具有与NO作用相反的细胞毒作用，并直接参与了缺血心肌损伤病理过程(Proc Natl Acad Sci USA, 1999)。上述发现被国际多个实验室证实，得到包括诺贝尔医学奖获得者LJ. Ignarro教授等国际同行的广泛重视和认可，论文被N Engl J Med等SCI杂志他引824次，其中在Circulation发表的单篇论文已被他引逾百次，成为心血管领域被引用率最高的“ 1%最有影响的论文” (ISI报告)，主要发现和观点被写入心脏病治疗学专著。上述发现揭示了胰岛素新的作用机制，尤其是胰岛素与心血管内源性NO系统的关系及其在心血管保护中的重要作用，为更有效保护缺血心脏、防治心血管胰岛素抵抗提供了新的线索。
主持科技部973课题(心脏保护的神经和体液机制)1项和国家自然科学基金课题面上项目4项
以第一完成人获陕西省科学技术一等奖和军队科技进步二等奖各1项; 发表SCI论文36篇，其中以第一或通讯作者在Circulation, Crit Care Med, Cardiovasc Res, J Hypertension, Am J Physiol, Br J Pharmacol, Apoptosis, JPET等SCI杂志发表论文19篇。
1.Insulin says NO to cardiovascular diseases
2.Survivin： A novel player in insulin cardioprotection against myocardial ischemia/reperfusion injury
3.Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress
4.Aldehyde Dehydrogenase 2 (ALDH2) Ameliorates Acute Cardiac Toxicity of Ethanol： Role of Protein Phosphatase and Forkhead Transcription Factor
5.Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
6.Aging-associated insulin resistance predisposes to hypertension and its reversal by exercise： the role of vascular vasorelaxation to insulin
7.Pressure-induced magnetic transition in metallic nickel hydrides by ab initio pseudopotential plane-wave calculations
8.Insulin inhibits β -adrenergic action in ischemic/reperfused heart： a novel mechanism of insulin in cardioprotection
9.Acute hyperglycemia exacerbates myocardial ischemia reperfusion injury and blunts cardioprotective effect of GIK
10.Long term aerobic exercise protects the heart against ischemiareperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism
11.Swim training sensitizes myocardial response to insulin Role of Akt-dependent eNOS activation
12.Hypoxic postconditioning enhances the survival and inhibits apoptosis of cardiomyocytes following reoxygenation：role of peroxynitrite formation
13.Physiologically Tolerable Insulin Reduces Myocardial Injury and Improves Cardiac Functional Recovery in Myocardial Ischemic/Reperfused Dogs
14.Vasculoprotective effect of insulin in the ischemic/reperfused canine heart role of Akt-stimulated NO production
15.Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion
16.Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart
17.Early Anti-Apoptosis Treatment Reduces Myocardial Infarct Size After A Prolonged Reperfusion
18.Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion
19.Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury
20.Mechanism of decreased adenosine protection in reperfusion injury of aging rats
***特聘教授
自2000年以来，获国家***科学基金和军队***基金
以第一完成人获陕西省科学技术一等奖和军队科技进步二等奖各1项
现为总后科技新星，享受***
