• 姓       名:郭林
  • 职       称:教授
  • 学       位:博士
  • 所在机构:武汉大学 生命科学学院
  • 出生年月:
  • 籍       贯:
  • 研究方向:蛋白质组学
个人简介 学术成果 发表论文

教育背景

学士,1983,武汉大学生物系

硕士,1986,武汉大学生物系

博士,1991,美国内华达大学生物化学系

工作经历

博士后, 1993-1995,美国弗吉利亚大学

博士后, 1995-1998,美国华盛顿大学

1998-2005.7,Immunex公司/Amgen公司,美国西雅图,历任初级科学家、科学家、高级科学家

2005.8.-至今,武汉大学生命科学学院教授

论文专著

代表性论文:

1.Chen, C., D. Wu, Leike Zhanga, Yong Zhao, Lin Guo. (2012). " Comparative phosphoproteomics studies of macrophage response to bacterial virulence effectors." Journal of Proteomics 77: 251-261.

2.Liu, G., H. Tian, Yun-Qing Huang, Jun Hu, Yan-Xiao Ji, Shao-Qing Li, Yu-Qi Feng, Lin Guo,and Ying-Guo Zhu (2012). " Alterations of Mitochondrial Protein Assembly and Jasmonic Acid Biosynthesis Pathway in Honglian (HL)-type Cytoplasmic Male Sterility Rice." Journal of Biological Chemistry 287(47): 40051-40060.

3.Yao, Q.,Li, H.,Liu, B. Q.,Huang, X. Y and L. Guo (2011). " SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses." J Biol Chem 286(31): 27342-9.

4.Yu, J. L. and L. Guo (2011). " Quantitative proteomic analysis of Salmonella enterica serovar Typhimurium under PhoP/PhoQ activation conditions." J Proteome Res 10(7): 2992-3002.

5.Chen, X., D. Wu, Y. Zhao, B. H. Wong and L. Guo (2011). " Increasing phosphoproteome coverage and identification of phosphorylation motifs through combination of different HPLC fractionation methods." J Chromatogr B Analyt Technol Biomed Life Sci 879(1): 25-34.

6.Wu, J. H., Y. Zhao, T. Li, C. Xu, K. Xiao, Y. Q. Feng* and L. Guo* (2010). " The use of liquid phase deposition prepared phosphonate grafted silica nanoparticle-deposited capillaries in the enrichment of phosphopeptides." J Sep Sci 33(12): 1806-15. (* co-corresponding author)

7.Ma, Y., Y. Zhao, R. Zhao, W. Zhang, Y. He, Y. Wu, Z. Cao*, L. Guo* and W. Li* (2010). " Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis." Proteomics 10(13): 2471-85. (* co-corresponding author)

8.Zhou, Z., J. B. Fan, H. L. Zhu, F. Shewmaker, X. Yan, X. Chen, J. Chen, G. F. Xiao, L. Guo and Y. Liang (2009). " Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding." J Biol Chem 284(44): 30148-58.

9.Deng, M., F. Li, B. A. Ballif, S. Li, X. Chen, L. Guo and X. Ye (2009). " Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17." J Biol Chem 284(12): 7875-88.

10.Deng, F., R. Wang, M. Fang, Y. Jiang, X. Xu, H. Wang, X. Chen, B. M. Arif, L. Guo and Z. Hu (2007). " Proteomics analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100." J Virol 81(17): 9377-85.

11.Guo, L., C. J. Kozlosky, L. H. Ericsson, T. O. Daniel, D. P. Cerretti and R. S. Johnson (2003). " Studies of ligand-induced site-specific phosphorylation of epidermal growth factor receptor." J Am Soc Mass Spectrom 14(9): 1022-31.

12.Guo, L., J. R. Eisenman, R. M. Mahimkar, J. J. Peschon, R. J. Paxton, R. A. Black and R. S. Johnson (2002). " A proteomic approach for the identification of cell-surface proteins shed by metalloproteases." Mol Cell Proteomics 1(1): 30-6.

13.Guo, L., R. S. Johnson and J. C. Schuh (2000). " Biochemical characterization of endogenously formed eosinophilic crystals in the lungs of mice." J Biol Chem 275(11): 8032-7.

14.Guo, L., K. B. Lim, C. M. Poduje, M. Daniel, J. S. Gunn, M. Hackett and S. I. Miller (1998). " Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides." Cell 95(2): 189-98.

15.Guo, L., K. B. Lim, J. S. Gunn, B. Bainbridge, R. P. Darveau, M. Hackett and S. I. Miller (1997). " Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ." Science 276(5310): 250-3.

16.Hackett*, M., L. Guo*, J. Shabanowitz, D. F. Hunt and E. L. Hewlett (1994). " Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis." Science 266(5184): 433-5. (co-first author)

奖励/荣誉

“ 奖励计划” 特聘教授。