• 姓       名:段树民
  • 职       称:教授
  • 学       位:博士
  • 所在机构:浙江大学 医学院
  • 出生年月: 1957年10月
  • 籍       贯:安徽省蒙城县
  • 研究方向:神经生物学
个人简介 学术成果 发表论文

教育背景

1982年毕业于蚌埠医学院

1991年在日本九州大学获博士学位

工作经历

1997-1999年先后在夏威夷大学和加州大学旧金山分校做博士后研究

2000-2009年在中国科学院神经科学研究所先后任研究员、神经科学国家重点实验室主任、副所长

学术兼职

任《Neuroscience Bulletin》主编,《Journal of Neurophysiology》、《Glia》、《Hippocampus》、《Neurobiology of Disease》等国际神经科学杂志编委。

全国政协委员, 中国神经科学学会理事长,亚太神经科学学会主席。

论文专著

1.Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng GP, Huang ZL, Duan* , and Yu YQ, Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep wake Transitions, Current Biology 2014 ( in press)

2.Wu HJ, Liu YJ, Li HQ, Chen C, Dou Y, Lou HF, Ho MS, Li XM, Gao Z, Duan S.

Analysis of microglial migration by a micropipette assay. Nat Protoc. 2014, 9: 491-500.

3.Li HQ, Chen C, Dou Y, Wu HJ, Liu YJ, Lou HF, Zhang JM, Li XM, Wang H, Duan S*. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Mol Cell Biol. 2013, 33: 4282-93.

4.Chen J, Tan Z, Zeng L, Zhang X, He Y, Gao W, Wu X, Li Y, Bu B, Wang W, Duan S*. Heterosynaptic long-term depression mediated by ATP released from astrocytes. Glia. 2013,61:178-191

5.Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, Li Y, Jia B, Thoreson WB, Ding W, Ding J, Zhao L, Wang Y, Wavrin KL, Duan S*, Zheng J*. CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway. Stem Cells. 2012, 30:2571-2583

6.Y Dou, HJ Wu, HQ Li, S Qin, HF Lou, QM Luo, Duan S*, Microglia Migration Mediated by ATP-Induced ATP Release from Lysosome, Cell Res, 2012 22:1022-1033

7.Li KX, Lu YM, Xu ZH, Zhang J, Zhu JM, Zhang JM, Cao SX, Chen XJ, Chen Z, Luo JH, Duan S, Li XM. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2012: 15,267–273

8.Ji Y, Lu Y, Yang F, Shen W, Tang TT, Feng L, Duan S, Lu B,.Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nat Neurosci. 2010, 13:302-309

9.Song AH, Wang D, Chen G, Li Y, Luo J, Duan S*, Poo MM. A selective filter for cytoplasmic transport at the axon initial segment. Cell. 2009, 136:1148-1160.

10.Tong XP, Li XY, Zhou B, Shen WH, Zhang ZJ, Xu TL, Duan S*,Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration, J Cell Biol, 2009, 186: 113-128

11.Li H, Chen G, Zhou B, Duan S*. Actin Filament Assembly by MARCKS- PI(4,5)P2 Signaling Is Critical for Dendrite Branching. Mol Biol Cell. 2008, 19: 4804-4813

12.Z-J Zhang, G Chen, W Zhou, A-H Song, W Wang, T Xu, Q-M Luo, X-S Gu, Duan S*, Regulated ATP release from astrocytes via lysosome exocytosis. Nature Cell Biol 2007, 9: 945-953.

13.Ge WP, Duan S*. Persistent Enhancement of Neuron-Glia Signaling Mediated by Increased Extracellular K+ Accompanying Long-Term Synaptic Potentiation. J Neurophysiol. 2007, 97: 2564-2569

14.Chen G, Li HM, Chen YR, Gu XS, Duan S*. Decreased estradiol release from astrocytes contributes to the neurodegeneration in a mouse model of Niemann-Pick disease type C. Glia 2007; 55:1509-1518.

15.Zhang X, Xu R, Zhu B, Yang X, Ding X, Duan S, Xu T, Zhuang Y, Han M. Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development. 2007, 134:901-908.

16.Wang, C., Zhang, L., Zhou, Y., Zhou, J., Yang, X., Duan, S., Xiong, Z., Ding, Y. (2007) Activity-dependent development of callosal projections in the somatosensory cortex. J. Neurosci. 27: 11334-11342

17.Ge WP, Yang XJ, Zhang ZJ, Wang HK, Deng QD, Duan S* Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors Science, 2006,312, 1533-1537

18.Shen W, Wu B, Zhang Z, Dou Y, Rao ZR, Chen YR, Duan S*. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuorn, 2006, 50: 401-414 (Cover)

Comment: Atasoy and Kavalali,Presynaptic Unsilencing: Searching for a Mechanism. Neuron, 2006, 50:345-346

19.Duan S*, Neary J, P2X7/P2Z receptors: properties and relevance to CNS functions (Invited review). Glia, 2006, 54:738-746.

20.Lu W, Zheng BJ, Xu K, Schwarz W, Du L, Wong CK, Chen J, Duan S, Deubel V, Sun B. Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release. PNAS, 2006, 103:12540-12545

21.Jin W, Ge WP, Xu J, Cao M, Peng L, Yung W, Liao D, Duan S, Zhang M, Xia J. Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity. J Neurosci. 2006 Mar 1;26(9):2380-90.

22.Xu X, Fu AK, Ip FC, Wu CP, Duan S, Poo MM, Yuan XB, Ip NY. Agrin regulates growth cone turning of Xenopus spinal motoneurons. Development. 132:4309-4316. (2005)

23.Pan, P., Cai, Q., Lin, L., Lu, P., Duan S*, and Sheng, Z. SNAP-29-mediated Modulation of Synaptic Transmission in Cultured Hippocampal Neurons. J. Biol.Chem. 280: 25769-25779 (2005)

24.Xu, H., Yuan, X., Guan, C., Duan, S., Wu, C., and Feng, L. Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration. PNAS, 101, 4296-4301 (2004)

25.Li, C., Wu, CP., Duan S*, and Poo, M. Bidirectional Modification of Presynaptic Neuronal Excitability Accompanying Spike Timing-Dependent Synaptic Plasticity. Neuron,41, 257–268 (2004)

26.Zhang, J. Wang, H., Ye, C., Ge, W., Chen, Y., Wu, CP., Poo, M., and Duan, S. ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression. Neuron, 40, 971-982 (2003)

Comment:O Pascual and PG. Haydon, Synaptic Inhibition Mediated by Glia. Neuron, 40, 873-875 (2003)

27.Yang, Y., Ge, W., Chen, Y., Wu, CP., Poo, M., and Duan, S*. Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. PNAS, 100, 15194 – 15199 (2003)

28.Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen Z, Rao Y, Geng JG. Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell. 4:19-29 (2003).

29.Wang, Z., Xu, N., Wu,CP., Duan S*,and Poo, M. Bidirectional Changes in Spatial Dendritic Integration Accompanying Long-Term Synaptic Modifications. Neuron, 37: 463-472 (2003)

30.Yuan X, Jin, M., Xu, X., Wu, CP., Poo, M., and Duan, S*. Signalling and crosstalk of Rho GTPases in mediating axon guidance. Nature Cell Biol, 5, 38 - 45 (2003)

31.Duan, S, C M. Anderson, E C. Keung, K.Farrell, Y. Chen, and RA. Swanson. P2X7 Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes. J Neurosci, 23: 1320-1328 (2003)

32.Anderson CM, Norquist BA, Vesce S, Nicholls DG, Soine WH, Duan S, Swanson RA. Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal death. J Neurosci. 22:9203-9209.(2002)

33.Xiang Y, Li Y., Zhang Z., Wang S., Yuan XB., Wu CP, Poo MM and Duan S*, Nerve growth cones guidance mediated by G-protein-coupled receptors. Nature Neuroscience, 5, 843 - 848 (2002)

34.Duan S, Cooke IM, Glutamate and GABA activate different receptors and Cl (-) conductances in crab peptide-secretory neurons. J Neurophysiol 83: 31-37 (2000)

35.Swanson R.A., Duan S., Regulation of glutamate transporter function (Review). Neuroscientist, 5: 280-282 (1999)

36.Duan S, Anderson CM, Stein BA, Swanson RA, Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST. J Neurosci 19:10193-10200 (1999)

37.Duan S, Cooke IM, Selective inhibition of transient K+ current by La3+ in crab peptide-secretory neurons. J Neurophysiol 81:1848-1855 (1999)

奖励/荣誉

2008年获何梁何利科学与进步奖,2010年获国家自然科学二等奖。